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Melanotan One (MT-1)

Afamelanotide (M-I) Dose:

Light: .5mg
Common: 1mg
Large: 2mg

Melanotan/Afamelanotide is a synthetic version of melanocyte stimulating hormone (a-MSH). Afamelanotide treatment induces skin pigmentation through melanogenisis, the production of melanin. Melanin prevents cellular damage in the skin by absorbing, reflecting and refracting light. Melanotan reduces sun damage to UV exposed skin in those with sun allergies.

melanotan before after treatment

Melanotan Results: Melanotan favors production of eumelanin (black/brown) over pheomelanin pigment. Injecting this linear amino acid peptide offers super-physiological levels of a-MSH. The fair skinned can achieve a photoprotective tan with Melanotan usage.

Fitzpatrick skin type chart

Research Use: The half-life of Melanotan peptides is very brief. Afamelanotide is being developed in implant form for the ease of use in dermatology. The implant contains 16mg which has a controlled release effecting melanin density for months. Melanotan One is offered in research peptide form (10mg Melanotan One). MT-1 gives the user greater control over dosing, however requires injections and expertise.

Lifestyle: Melanocortins have the potential to be the next big thing in lifestyle drugs (Viagra, Botox, etc). Patients who benefit from treatment have such variations when it comes to their goals, expectations and genetics. Melanotan can be appropriately used continuously as well as intermittently. Dose timing and missing doses are generally not concerns.

Recommended Therapy: Intermittent therapy, lasting 10 days (skin type III) to 6 months (skin type I) works well. Take note how long after your Melanotan administration melanin density stays elevated.

Peptide Molecule: Two amino acids present in the bodies natural a-MSH have been changed in production of Afamelanotide creating more stablity. Melanotan only works when injected subcutaneously.

Amino acid sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

Clinical Trial: Melanotan is still undergoing clinical trials and has not reached approved status. People use on the pretenses and understanding that it is for research purposes only. Users may suffer from slight nausea and flushing after subcutaneous injection; however it is reported to be mild and pass quickly.

Safety First: Melanotan One is a selective agonist of the MC1R (Melanocortin 1 receptor) and does not have aphrodisiac effects. Melanotan One does not cross the blood brain barrier. Melanotan is targeted specifically towards one of the five melanocortin receptors and continues to be research in clinical study.

Patience: Melanotan One is less efficacious than its counterpart Melanotan 2 for achieving a dark tan. Afamelanotide will therefore require 8-10x the dosage to see comparable results. Melanotan One users want minimum side and peripheral effects with a focus on photoprotection. Be patient and prepared through your Melanotan journey.

Administration of Research Melanotan

Safe and controlled administration of Afamelanotide for research is done much like that of Melanotan 2. Melanotan One offered as a peptide in a multi-dose sterile vial is desirable. Implants, nasal sprays and pills are not applicable/efficacious at the present time.

Melanotan Treatment: Dosing According to Skin Type

Fitzpatrick Skin Type I: 1mg-2mg/day. 100mg total may be necessary to achieve desired color. UV exposure after at least 20mg in system
Fitzpatrick Skin Type II: .75mg-1.5mg/day. 60mg should be sufficient to get color. UV exposure after 10-20mg
Fitzpatrick Skin Type III: .5mg-1mg/day. A sunless tan may be realistic
Fitzpatrick Skin Type IV: Do not use Melanotan

Melanotan Video from Australia

Melanotan can assist the develop a protective tan in users. A natural tan is developed in response to cell damage caused by UV radiation. Ultraviolet rays penetrate the upper layers of the skin, triggering a-MSH, stimulating melanin production. Melanin deposits act as a natural sunblock at the cellular level. Melanotan tanning injections may offer a way to bring upon a safe, cosmetic tan with less damage.